Aim: Uterin sarcomas are one of the agresive gynecologic malignencies. There is still no optimal test for preoperative diagnosis of uterin sarcomas. The aim of this study was to evaluate the role of NLR, PLR, and APRI score in predicting preoperative uterine sarcoma. Materials and Methods: Patients operated on between January 2010 and December 2020 histopathologically diagnosed as sarcoma were included in the study group. Patients who were histopathologically diagnosed with M. uteri were included as the control group during the same period. Age, BMI (body mass index), gravida, parity, preoperative mean platelet volume (MPV), platelet distribution width (PDW), red cell distribution width (RDW), NLR,PLR and APRİ scores were recorded. Results: When comparing patients with fibroids and sarcomas, hemoglobin [12.3 (6.4-15.4) vs. 11.3 (6-17), p=0.008, respectively], hematocrit [38.5 (22-48.7) vs. 35.9 (21.4-52.1), p=0.002, respectively] and lymphocyte levels [2.2 ( 0.9-13.8) vs. 1.8 (1-2.6), p 0.001, respectively] were significantly lower and NLR [1.7 (0.2-10.1) vs. 2.3 (1.4-5.9), p 0.001, respectively] and PLR [124 (10.9-352.1) vs. 180.4 (84.9-284.3), p 0.001, respectively] were significantly higher in sarcoma group. The optimal cut-off value for NLR and PLR was calculated to be 2.04 with sensitivity and specificity of 59.4% and 59.5%, respectively, and 150.7 with sensitivity and specificity of 65.6% and 64.7%, respectively.
Conclusion: Preoperative NLR and PLR rates can be useful markers for diagnosing uterine sarcoma. Randomized controlled large series studies are necessary to make a definitive statement.
Anahtar Kelimeler: Uterine sarcoma, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, APRI score